The skin treatment that fills nothing.

Short chains of DNA, purified from salmon or trout, injected into the skin to improve its texture, tone and hydration. They add no volume. Instead they prompt the cells that make collagen and elastin, so the change develops over about eight weeks. London Polynucleotides talks about a course rather than a treatment for that reason.

Mainly for skin quality rather than shape: crepiness, dullness, uneven texture, and the tired look that comes from thin skin under the eyes. They are also used on the neck, the décolletage and the hands. They will not fill a hollow or lift anything.

It depends on why the area looks dark, and it is the question London Polynucleotides is asked most. Where the skin under the eye is thin and the vessels show through it, polynucleotides often make a visible difference. Where the shadow comes from a hollow tear trough or pigmentation, they help much less. An assessment should name the cause first.

Published London prices generally start from a few hundred pounds a session, and a course is usually three sessions. What you are quoted turns on the area, the number of vials and the length of the course. London Polynucleotides publishes no price of its own, because it treats nobody. Ask whether a number is per session or per course.

A completed course generally holds for six to nine months. The injected material itself is gone within days, and what persists is the tissue response it triggered, so the range is wide and depends on your age, your skin and how much sun the area gets.

No. A filler is a gel that adds volume where the face has lost it, and it changes shape on the day. Polynucleotides add no volume at all. They change the condition of the skin over about eight weeks, so the two treatments answer different problems and are not interchangeable.

Not on this site. London Polynucleotides publishes no gallery, because it treats nobody, so any photograph here would be another clinic's patient used as decoration. Ask whoever assesses you for their own results: same light, same angle, same stage of a course, and on skin something like yours. A gallery that cannot meet those four conditions is telling you little.

Small raised bumps at each injection point for one to three days, some swelling, and bruising that is commonest around the eyes. Tenderness for a day is normal. Anything that spreads, throbs or comes with heat needs the person who injected you to look at it the same day, which argues for a clinic that answers the phone.

Anyone pregnant or breastfeeding, anyone with an active skin infection in the area, and anyone with a known fish allergy, since the source material is salmon or trout. Tell whoever assesses you about autoimmune conditions and about anything you take that affects clotting.

Anyone injecting you should be a doctor, dentist, nurse or pharmacist prescriber with specific training in this treatment, working somewhere equipped to manage a complication. Ask what their registration is, then check the number yourself on the public register. London Polynucleotides names no practitioner, so this check is yours.

An independent guide to one treatment, owned by the UNTIL group. London Polynucleotides holds no clinic, has no treatment room and injects nobody, which is why there is no price list, no practitioner biography and no gallery on it. It connects you to a registered practitioner through UNTIL Health Concierge for an assessment in person.

The UNTIL group runs four private health and fitness clubs in central London and works with independent practitioners who hold clinic inside them. Enquiries from this site go to UNTIL Health Concierge, who arrange an assessment with a registered clinician. Nothing is paid per enquiry, and the relationship is disclosed in the footer of every page.

Very little changes in the first fortnight. Most people notice the skin looking less dull from around week four, after the second session, and the fullest effect lands at eight to twelve weeks. Judge the course at week eight against how the area looked before you started, not in the days after a session.